Similar to the Pocketville Princess franchise, the Pocketville Villains have their own franchise that consists of the show's most well-known and beloved villains. While the Princess line has the biggest selection, Villains has the most characters.
- Dogo Argentino
- Cobra Commander
- Canis and Lupis
- Scar's parents
- Peaches (later well-mannered)
- Willis (later on reformed and well-mannered)
Note: Some of these villains are considered the greatest "Puppy in My Pocket" villains of all time